MTHFR Pregnancy: The Methylation Cycle
Folate Methylation
The MTHFR enzyme is the rate limiting factor for converting synthetic folic acid or folinic acid to the active form of folate.
Oral doses of L-methylfolate become immediately available to the cell and are used to convert homocysteine to methionine. Only reduced folates are functional and essential for the DNA biosynthesis cycle.
Néevo® is a medical food for use only under medical supervision for the dietary management of impaired metabolic processes in women under a doctors care who face high to intermediate risk pregnancies and are unable to fully metabolize or absorb folic acid.
L-methylfolate is 7 times more bioavailable than folic acid.*
* Malloy A. et al. Thermolabile variant of 5, 10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. The Lancet 1997; 349: 1591-93.